Download PDFOpen PDF in browserUncovering the particularities of the dynamical interaction between cancer-related Epithelial-Mesenchymal Transition and the Mammalian Cell Cycle: a feedback-based Boolean networks interconnection approach10 pages•Published: May 1, 2023AbstractEpithelial-to-Mesenchymal Transition (EMT) plays a key role in epithelial-cancer. The state trajectory of its underlying Gene Regulatory Network (GRN) includes three fixed-point attractors characterizing epithelial, senescent, and mesenchymal, cell phenotypes, which implies specific cell-to-cell and cell-to-tissue interactions. The interplay between the GRN driving EMT and the one regulating the Mammalian Cell Cycle (MCC) influences cancer- related cell growing and proliferation. We expose the characteristics of the network arising from the interconnection of the gene regulatory networks associated to EMT and MCC. Our purpose is twofold: first, to elucidate the dynamical properties of cancer-related gene regulatory networks. Subsequently, to propose a computational methodology to address the interconnection of networks related to cancer. Our approach is based on feedback-based interconnection of networks described in discrete Boolean terms.Keyphrases: complex networks, discrete boolean networks, epithelial cancer, epithelial to mesenchymal transition, feedback based interactions, gene regulatory networks, mammalian cell cycle, systems biology of cancer In: Hisham Al-Mubaid, Tamer Aldwairi and Oliver Eulenstein (editors). Proceedings of International Conference on Bioinformatics and Computational Biology (BICOB-2023), vol 92, pages 1-10.
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